St. John's Wort Extract

St. John's Wort has hormone-modulating activity and significantly interacts with many medications (it induces liver enzymes that metabolize a huge range of drugs) — generally avoided in pregnancy, and any use requires medical coordination given the interaction risk alone.

Some case reports describe infant drowsiness/colic when the nursing parent used St. John's Wort; combined with its extensive drug-interaction profile, it's generally avoided while nursing.

Not typically used in children given its significant drug-interaction profile and hormone-modulating activity.