Condition

Lyme Disease Support

Lyme disease is a systemic bacterial infection caused by Borrelia burgdorferi — a spiral-shaped spirochete bacterium transmitted through the bite of infected Ixodes deer ticks. After inoculation, Borrelia disseminates rapidly through the bloodstream and lymphatics, invading joints, the nervous system, the heart, and collagen-rich connective tissue within days to weeks. The characteristic bullseye rash (erythema migrans) appears in 70–80% of early infections but is frequently missed or misidentified. What makes Borrelia exceptionally difficult to clear is its sophisticated immune evasion: it downregulates outer surface proteins to evade antibody recognition, undergoes VlsE antigenic variation to escape immunological memory, forms protective biofilm colonies in joint and connective tissue, and shifts into dormant cyst forms when challenged by antibiotics — permitting persistence despite treatment. Late-stage Lyme disease involves Lyme arthritis (inflammatory joint swelling from Borrelia antigen deposition and immune complex formation), Lyme neuroborreliosis (cognitive impairment, peripheral neuropathy, encephalopathy), and Lyme carditis (heart block from bacterial invasion of the cardiac conduction system). Post-treatment Lyme Disease Syndrome (PTLDS) affects 10–15% of patients who complete antibiotic courses — characterised by persistent fatigue, musculoskeletal pain, and cognitive impairment lasting months to years, driven by residual inflammation, immune dysregulation, bacterial persistence in sheltered compartments, and nervous system sensitisation. Tick bites frequently transmit multiple co-pathogens simultaneously: Bartonella (causing neurological symptoms), Babesia (causing a malaria-like haemolytic syndrome), and Ehrlichiosis — requiring a protocol that addresses co-infection complexity. Holistic support focuses on antimicrobial herbs that penetrate biofilm and tissue compartments (cat's claw uncaria alkaloids, Japanese knotweed resveratrol, andrographis andrographolide), immune modulation, joint anti-inflammatory support (Boswellia, turmeric), nervous system restoration, and mitochondrial repair for the profound fatigue that accompanies late-stage and post-treatment disease.

Safety notice — MEDIUM

Sunaras provides educational wellness content only. This is not medical advice, diagnosis, or treatment. Individual responses to herbs vary. Always consult a qualified healthcare practitioner for personalised guidance.

Ginseng may lower blood sugar (caution with insulin or diabetes medications), interact with MAOIs potentially causing manic episodes, and alter warfarin efficacy. Avoid in oestrogen-sensitive cancers.

Cat's Claw Bark (Uncaria tomentosa — Primary Anti-Borrelial)

Cat's Claw is the cornerstone herb of evidence-based Lyme botanical protocols. Its pentacyclic oxindole alkaloids (POAs) — particularly isopteropodine, pteropodine, and mitraphylline — stimulate macrophage phagocytosis and lymphocyte production, enhancing immune clearance of Borrelia burgdorferi. Quinovic acid glycosides directly inhibit NF-κB — the master regulator of the inflammatory cytokine cascade responsible for Lyme arthritis, neurological inflammation, and the systemic symptoms of late-stage Lyme disease. Crucially, Cat's Claw has demonstrated direct in vitro activity against B. burgdorferi, and its proanthocyanidins disrupt the protective biofilm matrix that Borrelia forms in joint tissue — making bacteria accessible to both immune cells and antibiotic therapy. A 2005 study in the Journal of Ethnopharmacology confirmed significant anti-Borrelia activity at concentrations achievable with standard extract dosing. Use the TOA-free (tetracyclic oxindole alkaloid-free) preparation — TOAs block the immunomodulatory effects of the beneficial POA alkaloids.

⚠️ Not in pregnancy or breastfeeding. Do not combine with immunosuppressant medications. May enhance anticoagulant effects of blood thinners — monitor. Do not use with organ transplant immunosuppression. Some preparations (not TOA-free) are adulterated with inferior species — use reputable sources. May cause mild Herxheimer reactions (temporary worsening before improvement) — reduce dose if this occurs.

Amazonian / Andean

Japanese Knotweed Root (Reynoutria japonica — Resveratrol and BBB Penetrator)

Japanese Knotweed is the richest plant source of resveratrol — a stilbene polyphenol with exceptional properties for neurological Lyme disease. Resveratrol is one of the few plant compounds that reliably crosses the blood-brain barrier in therapeutic concentrations, making Japanese Knotweed uniquely valuable for Lyme neuroborreliosis — where Borrelia infects the central nervous system causing cognitive impairment, encephalopathy, and neuropsychiatric symptoms. Resveratrol directly inhibits Borrelia burgdorferi replication through DNA gyrase inhibition in laboratory studies. Beyond the direct anti-borrelial activity, Japanese Knotweed powerfully downregulates the cytokine storm that drives Lyme's most debilitating symptoms: it inhibits TNF-α, IL-1β, IL-6, and COX-2 simultaneously through NF-κB suppression. Emodin — an anthraquinone from the root — has demonstrated anti-spirochetal activity and provides additional anti-inflammatory effects. Herbalist Stephen Buhner, who developed the most widely used herbal Lyme protocol, considers Japanese Knotweed the most important single herb for neurological and late-stage Lyme.

⚠️ Not in pregnancy. May interact with blood thinners (resveratrol has mild antiplatelet activity). High doses may cause GI discomfort — take with food. Not in severe kidney disease. Japanese Knotweed is an invasive species — source from reputable commercial suppliers rather than foraging. The root, not the aerial parts, contains therapeutic concentrations of resveratrol.

Traditional Chinese Medicine / Japanese Traditional Medicine

Andrographis (Andrographis paniculata — Anti-Spirochetal and Co-Infection)

Andrographis is one of the most extensively researched anti-borrelial herbs, with andrographolide — its primary diterpene lactone — demonstrating direct activity against B. burgdorferi in multiple laboratory studies. A landmark 2020 study from Johns Hopkins (Feng et al.) screened 34 plant compounds against Borrelia persister cells and statilised cultures — andrographolide demonstrated activity superior to the front-line antibiotic doxycycline against stationary-phase Borrelia, the form most resistant to standard antibiotic treatment. Beyond Borrelia itself, andrographolide is active against Bartonella (the most common Lyme co-infection, causing neurological symptoms, joint pain, and lymph node swelling), Ehrlichia, and Anaplasma — making it essential when co-infections are suspected. Andrographolide activates macrophages and NK cells, boosts T lymphocyte production, and reduces fever and systemic inflammation through NF-κB and IL-2 modulation.

⚠️ Very bitter — GI discomfort common at high doses, especially on an empty stomach. Take with meals. Not in pregnancy (uterine stimulant at high doses). Not in active autoimmune conditions where immune stimulation may worsen disease. May lower blood pressure at high doses — monitor if on antihypertensives. Not with immunosuppressants. Some people experience temporary Herxheimer reactions — reduce dose if this occurs and increase more slowly.

Ayurveda / Traditional Chinese Medicine / Thai Traditional Medicine

Cryptolepis sanguinolenta (West African Antimicrobial — Anti-Borrelial and Anti-Babesia)

Cryptolepis sanguinolenta is a West African medicinal vine whose alkaloids — cryptolepine, quindoline, and biscryptolepine — have demonstrated among the strongest anti-Borrelia activity of any plant compound tested. The 2020 Johns Hopkins persister cell screening study (Feng et al.) identified Cryptolepis root tincture as one of just seven natural compounds with activity superior to doxycycline against stationary-phase Borrelia — the cyst forms and persister cells that are believed to underlie post-treatment Lyme syndrome. Crucially, Cryptolepis also demonstrates significant anti-Babesia activity: cryptolepine directly disrupts the intraerythrocytic life cycle of Babesia microti and B. duncani, the protozoan parasites most commonly co-transmitted with Borrelia by Ixodes ticks. This dual Borrelia/Babesia activity makes Cryptolepis particularly valuable when Babesia co-infection (causing sweats, chills, and haemolytic anaemia) is suspected alongside Lyme disease.

⚠️ Not in pregnancy (potential teratogen — alkaloid-containing herbs avoid in pregnancy). Not with immunosuppressants. May potentiate blood sugar-lowering medications (cryptolepine has hypoglycaemic activity — monitor blood glucose). Limited long-term human safety data — use under practitioner guidance. Do not use in sickle cell disease. Do not exceed recommended doses — alkaloid toxicity possible at high doses.

African Traditional Medicine (Ghana, Nigeria)

Teasel Root (Dipsacus fullonum / sylvestris — Tissue-Directing Lyme Herb)

Teasel root has a distinctive and specific role in Lyme herbal protocols that differentiates it from general antimicrobial herbs: it is used to direct therapeutic compounds specifically into the collagen-rich connective tissue, joint capsules, and fascial planes where Borrelia burgdorferi establishes its deepest and most antibiotic-resistant tissue reservoirs. Borrelia has evolved to target collagen because joints and connective tissue have reduced immune surveillance and antibiotic penetration. Teasel root — through mechanisms involving its iridoid glycosides (particularly loganin and sweroside) and saponins — is believed to act as a herbal 'guide' that enhances the penetration of co-administered herbs into these tissue compartments. Herbalist Matthew Wood pioneered the clinical use of teasel root for Lyme in the 1990s, and its inclusion in Lyme protocols became widespread through the report of significant symptom relief in Lyme arthritis, joint pain, and deep musculoskeletal symptoms. Some practitioners also note it helps mobilise Borrelia from tissue reservoirs — which may temporarily worsen symptoms before improvement (a Herxheimer-like response specific to teasel).

⚠️ Begin with very low drop doses — mobilising Borrelia from tissue can cause significant temporary symptom flares. Not in pregnancy. Limited clinical research — use is based on extensive practitioner experience and case reports rather than RCT evidence. Not a stand-alone treatment — used specifically to enhance penetration of other anti-borrelial herbs. Source from reputable herbal suppliers.

European Traditional Medicine / Western Herbalism

Sarsaparilla Root (Smilax sarsaparilla — Endotoxin Binder and Herxheimer Support)

Sarsaparilla occupies a uniquely important supportive role in Lyme herbal protocols: it binds and neutralises the endotoxins released by Borrelia spirochetes as they are killed by antibiotic or herbal treatment. The Jarisch-Herxheimer reaction — a temporary worsening of Lyme symptoms as Borrelia dies and releases lipopolysaccharide-like surface proteins, inflammatory toxins, and cell wall debris — is one of the most challenging aspects of Lyme treatment, causing fever, sweating, intense fatigue, joint flares, and neurological symptoms. Smilax root contains steroidal saponins (sarsaponin, smilagenin, sitosterol) with a molecular structure that binds spirochetal endotoxins in the gut and bloodstream, preventing their systemic absorption and reducing Herxheimer severity. Stephen Buhner specifically recommends Sarsaparilla for Herxheimer management, noting that it is most effective when taken 30 minutes before anti-borrelial herbs. It also has direct anti-inflammatory and mild immune-modulating properties.

⚠️ Generally well tolerated. May cause GI discomfort in large amounts — take with or after food. Not in pregnancy. Large amounts may increase the renal excretion of urates and chlorides — beneficial for gout but monitor in kidney disease. Do not confuse with false sarsaparilla species (Hemidesmus indicus) — different plant with different properties.

Indigenous South American / Caribbean / Western Herbalism

Artemisia annua (Sweet Wormwood — Anti-Babesia and Anti-Spirochetal)

Artemisia annua — the source of artemisinin, the Nobel Prize-winning anti-malarial compound — is essential in Lyme co-infection protocols when Babesia is present. Babesia microti and B. duncani are intraerythrocytic protozoan parasites transmitted by the same Ixodes ticks that carry Borrelia, with co-infection estimated in 20–40% of Lyme cases. Standard Lyme antibiotics (doxycycline, amoxicillin) have no activity against Babesia — requiring separate treatment with atovaquone-azithromycin or quinine-clindamycin. Artemisinin directly kills intraerythrocytic Babesia through the same mechanism it kills Plasmodium: it generates reactive oxygen species inside red blood cells upon reacting with intracellular iron, destroying the parasite's membrane. Beyond anti-Babesia activity, the 2020 Feng et al. Johns Hopkins study identified artemisinin as one of seven natural compounds with superior activity against Borrelia persister cells compared to doxycycline. Whole Artemisia annua plant (not isolated artemisinin) is used — the plant matrix appears to enhance bioavailability and provide complementary bioactive compounds.

⚠️ Not in pregnancy. Not in seizure disorders (artemisinin compounds have neurotoxicity at very high doses — use within recommended range). Cycle use (3 weeks on, 1 week off) to prevent tolerance and reduce potential neurotoxicity. Not a replacement for medical treatment in acute Babesia infection. Do not take with iron supplements — while iron enhances anti-parasitic activity, excess free iron can be harmful. Check current medications for CYP3A4 interactions. Source from reputable suppliers — artemisinin content in commercial herbs varies widely.

Traditional Chinese Medicine (Qinghao)

Olive Leaf Extract (Oleuropein — Anti-Borrelial Broad-Spectrum Antimicrobial)

Olive leaf extract provides oleuropein — a secoiridoid compound with documented antimicrobial activity against Borrelia burgdorferi, and synergistic activity across the full range of Lyme co-pathogens including Bartonella, Ehrlichia, Anaplasma, and Epstein-Barr virus (commonly reactivated in late-stage Lyme). Oleuropein's antimicrobial mechanism involves disrupting the bacterial membrane's ability to produce amino acids essential for replication, interfering with viral envelope formation, and inhibiting reverse transcriptase. For Lyme specifically, oleuropein has demonstrated activity against both the spirochetal form and — importantly — the cyst and biofilm forms of B. burgdorferi in laboratory studies. Olive leaf extract also supports the immune defences that are often significantly impaired in chronic Lyme: it stimulates phagocytic activity of macrophages, enhances NK cell function, and reduces the chronic systemic inflammation that causes the profound fatigue, joint pain, and cognitive impairment of late-stage and post-treatment Lyme disease.

⚠️ Well tolerated at recommended doses. May cause mild Herxheimer reaction when first starting, particularly in active infection — begin at lower dose and increase. GI discomfort possible — take with food. May lower blood pressure (oleuropein inhibits ACE enzyme) — monitor if on antihypertensives. Not in pregnancy. May enhance hypoglycaemic medications — monitor blood glucose.

Mediterranean Traditional Medicine

Oregano Oil / Carvacrol (Biofilm Disruptor — Persister Cell Active)

Oil of oregano — standardised for carvacrol and thymol content — was identified in the landmark 2019 Johns Hopkins University study (Feng et al., Antibiotics journal) as one of just two essential oil preparations with activity against Borrelia biofilm and persister cells superior to the current combination antibiotic therapies. This is clinically significant: biofilm-protected and persister-phase Borrelia are the dominant reason Lyme disease persists despite antibiotic treatment. While antibiotics effectively kill the motile spirochetal form of Borrelia, the non-replicating persister cells and biofilm-embedded colonies are essentially antibiotic-tolerant — not resistant (no genetic change), but physiologically dormant and therefore unaffected by antibiotics that target active replication. Carvacrol disrupts these persister cells by penetrating and depolarising their membranes — a physical mechanism that works regardless of bacterial metabolic state. Thymol acts synergistically. The Johns Hopkins study used oil of oregano at a concentration equivalent to approximately 1 drop per millilitre of tissue fluid.

⚠️ Strong phenolic compound — causes significant mucosal burning if taken undiluted. ALWAYS dilute in olive oil or use capsule form. GI irritation common at high doses — enteric-coated capsules minimise this. Cycle to prevent gut microbiome disruption (carvacrol kills beneficial bacteria as well as pathogens). Not in pregnancy. May increase bleeding risk — avoid with anticoagulants. Not for extended continuous use above 4 weeks without a break.

Mediterranean Traditional Medicine / Western Herbalism

Eleuthero / Siberian Ginseng (Adaptogen for PTLDS Fatigue and HPA Recovery)

Eleuthero (Eleutherococcus senticosus) — the original 'adaptogen' — is essential for the post-treatment and recovery phase of Lyme disease, addressing the profound, treatment-resistant fatigue, cognitive impairment, and immune dysfunction that characterise Post-Treatment Lyme Disease Syndrome (PTLDS). PTLDS involves HPA axis dysregulation (the same cortisol rhythm disruption seen in ME/CFS), mitochondrial dysfunction causing cellular energy failure, persistent low-grade neuroinflammation, and immune system exhaustion from months or years of fighting chronic infection. Eleutherosides B and E — the primary active compounds — modulate the HPA axis, reducing the blunted, dysregulated cortisol pattern of PTLDS toward a normal diurnal rhythm. They also activate NK cells and cytotoxic T lymphocytes (depleted in chronic Lyme), upregulate interferon-γ production (for ongoing Borrelia immune surveillance), and directly stimulate mitochondrial ATP production in fatigued cells. Unlike the more stimulating Panax ginsengs, Eleuthero produces gradual, sustained energy restoration without the cortisol spike that can worsen HPA dysregulation in PTLDS.

⚠️ Well tolerated. Mild stimulant — avoid in the evening. Not recommended in acute infections (may be overly stimulating to an already activated immune system). Not in pregnancy at therapeutic doses. May interact with digoxin — do not combine without medical supervision. Some sources note it may slightly elevate blood pressure — monitor in hypertension. Avoid with medications that are CYP3A4 sensitive.

Traditional Chinese Medicine / Russian Folk Medicine

Cistus

Cistus incanus

Traditionally used in Mediterranean for immune support, skin health, inflammation.

Preparation:

  • Infusion or powder: Steep as a tea, or grind and fill into size-00 capsules.
  • Can also be added to smoothies or warm water.

Dosage:

  • 1–3 cups daily, or 500 mg–1 g as powder/capsule

⚠️ Not Medical Advice: This information is for educational purposes only. Always consult a qualified healthcare provider before using herbal remedies.

Avoid if:

  • Pregnancy & breastfeeding — insufficient safety data; consult your doctor
  • Children under 12 — therapeutic dosage not established
  • Autoimmune conditions (lupus, MS, RA) — may overstimulate immune response

Mediterranean

Full profile

Wild Garlic and Cooked Garlic (Allicin — Anti-Borrelial and Biofilm Disruption)

Garlic allicin has demonstrated direct in vitro activity against Borrelia burgdorferi in multiple studies. The 2020 Johns Hopkins persister cell study identified garlic extract as one of the top seven natural compounds active against stationary-phase Borrelia, outperforming doxycycline in persister cell activity. Allicin — released when raw garlic is crushed and allowed to rest 10 minutes — disrupts Borrelia membrane integrity and inhibits biofilm formation. Thiosulfinates from garlic are also active against Babesia and Bartonella. High garlic intake also supports the liver's detoxification of Borrelia endotoxins released during die-off.

Preparation:

  • Crush 3–5 cloves of raw garlic and rest for 10 minutes before eating (allows allicin formation).
  • Eat raw in dressings, on toast, or in cold dishes.
  • Lightly cooked garlic retains significant allicin.
  • Garlic capsules (allicin-releasing, Allicin Max or similar): 180–360mg allicin daily.
  • Combine in cooking with turmeric, ginger, and olive oil for synergistic anti-borrelial nutrition.

Dosage:

  • 3–5 cloves daily raw or lightly cooked, ongoing throughout treatment

Mediterranean / Global Traditional

Wild Salmon, Sardines and Omega-3 Rich Fish (Neuroinflammation Reduction)

Omega-3 EPA and DHA are critical for neurological Lyme — where chronic neuroinflammation causes brain fog, memory impairment, mood disturbances, and cognitive impairment. EPA produces resolution-phase lipid mediators (resolvins, protectins) that actively terminate the neuroinflammatory cascade — not merely suppressing it, but driving it to resolution. DHA is the primary structural lipid of neuronal cell membranes and myelin sheaths; chronic neuroinflammation degrades DHA from membranes, impairing synaptic function and cognitive performance. For Lyme fatigue and joint pain, omega-3s reduce the IL-1β and TNF-α-driven inflammatory signalling that perpetuates joint and muscle pain after Borrelia is cleared.

Preparation:

  • Eat 200g wild salmon, sardines, or mackerel 4–5× per week.
  • Supplement with high-quality triglyceride-form fish oil: 3–4g EPA+DHA daily throughout Lyme treatment.
  • Sardines provide the highest omega-3 to cost ratio and lowest mercury.
  • Avoid farmed salmon (lower omega-3, higher omega-6, potential toxins).

Dosage:

  • 4–5 servings weekly, throughout the full Lyme treatment period and beyond for neurological Lyme

Mediterranean

Beets, Cruciferous Vegetables and Liver-Supporting Foods (Herxheimer Detox)

Herxheimer reactions — the toxic die-off symptoms from Borrelia being killed — are driven by the accumulation of spirochetal endotoxins, cell wall proteins, and inflammatory debris that the liver must process and eliminate. Supporting hepatic detoxification is critical throughout Lyme treatment. Beets provide betaine (protecting liver methylation capacity), beet fibre (binding endotoxins in the gut), and betalains (anti-inflammatory liver protectants). Cruciferous vegetables (broccoli, Brussels sprouts, kale) stimulate Phase II liver detoxification via sulforaphane-NRF2 activation, accelerating the clearance of spirochetal debris. Artichoke leaf stimulates bile production — the primary excretory route for Borrelia-derived toxins.

Preparation:

  • Daily: minimum 1–2 cups cruciferous vegetables (broccoli, cauliflower, kale, Brussels sprouts), 1 medium beet or beetroot juice, artichoke hearts or artichoke leaf tea.
  • Milk thistle tea (silymarin) daily as a hepatoprotective.
  • Drink 2–3L of filtered water daily throughout treatment — adequate hydration is essential for endotoxin excretion.

Dosage:

  • Daily throughout treatment — liver support is non-negotiable during active Borrelia die-off

Western Herbal / Mediterranean

Anti-Inflammatory Herbs and Spices (Turmeric, Ginger, Cinnamon — Daily Protocol)

A core anti-inflammatory culinary protocol targeting the cytokine storm that drives Lyme's most debilitating symptoms: joint pain, neurological inflammation, and systemic fatigue. Turmeric curcumin inhibits NF-κB and reduces TNF-α, IL-1β, and IL-6 — the primary inflammatory mediators in Lyme arthritis and neurological Lyme. Ginger gingerols and shogaols inhibit both COX-2 and 5-LOX prostaglandins and leukotrienes in inflamed joint tissue. Cinnamon reduces the blood sugar spikes that worsen systemic inflammation and impair immune function — critical since Borrelia thrives in inflammatory, high-glucose environments.

Preparation:

  • Daily culinary use: 1–2 tsp turmeric + ¼ tsp black pepper (activates curcumin absorption) in cooking.
  • 2–3 cm fresh ginger in cooking and teas.
  • ½–1 tsp cinnamon daily.
  • Supplement with high-bioavailability curcumin (BCM-95 or phytosome form) 500–1000mg 2× daily for therapeutic levels.
  • 'Golden paste' (turmeric + coconut oil + black pepper): ½ tsp daily.

Dosage:

  • Daily throughout treatment — anti-inflammatory culinary foundation of the Lyme diet

Ayurveda / Mediterranean

Active Lyme Anti-Borrelial Protocol Diet

Western Integrative Medicine

  • A comprehensive anti-inflammatory, liver-supporting, immune-activating diet for the active treatment phase of Lyme disease — working alongside herbal and/or antibiotic anti-borrelial therapy.
  • The diet prioritises five goals: (1) reducing systemic inflammation to lower the Herxheimer reaction and cytokine-driven symptoms; (2) supporting liver detoxification of spirochetal endotoxins released during Borrelia die-off; (3) providing anti-borrelial dietary compounds (garlic allicin, olive leaf oleuropein) in concentrated food form; (4) supplying omega-3s for neuroinflammation control in neurological Lyme; and (5) maintaining immune strength through nutrient density and eliminating the processed foods and sugars that impair immune cell function.
  • Note: Borrelia appears to exploit collagen and must be starved of inflammatory substrates — high-sugar, high-processed food diets worsen Lyme symptoms through increased systemic inflammation and immune suppression.

Foods:

  • Raw and lightly cooked garlic 3–5 cloves daily (allicin — anti-borrelial, anti-biofilm)
  • Wild salmon, sardines, mackerel (omega-3 — neuroinflammation control, 4–5×/week)
  • Cruciferous vegetables daily (sulforaphane — liver Phase II detox, Herxheimer support)
  • Beets 4× weekly (betaine — liver support, nitrates — circulation)
  • Turmeric + black pepper daily in cooking (curcumin — NF-κB inhibition)
  • Ginger daily (COX-2/5-LOX inhibition — joint and systemic inflammation)
  • Dark leafy greens 2+ cups daily (folate, magnesium, antioxidants)
  • Olive oil as primary fat (oleuropein — anti-borrelial, anti-inflammatory)
  • Artichoke hearts and milk thistle tea (bile stimulation — endotoxin excretion)
  • Eliminate: sugar, refined carbohydrates, alcohol, processed foods, gluten (if reactive)

Timing:

  • On waking: Anti-borrelial green detox juice (beet, celery, ginger, turmeric, lemon, spinach) — Sarsaparilla tincture 30 min before if Herxing
  • Breakfast: 2–3 eggs + sautéed spinach with 3 cloves garlic + avocado + milk thistle tea
  • Morning herbs: Buhner core tincture (Cat's Claw + Japanese Knotweed + Andrographis) in warm water
  • Lunch: Wild salmon over large salad with beet, mixed greens, olive oil-lemon-garlic dressing + cruciferous vegetables + turmeric-ginger soup
  • Afternoon: Japanese Knotweed + Cat's Claw decoction tea (2nd dose) + walnuts
  • Dinner: Sardines or mackerel with roasted broccoli-cauliflower (cruciferous) + wilted garlic kale + lemon
  • Evening: Eleuthero-Astragalus recovery tea (recovery phase only) + magnesium glycinate 400mg
  • Daily supplements: Allicin garlic 360mg, Fish oil 3–4g EPA+DHA, Curcumin phytosome 1000mg, Magnesium glycinate 400mg, Vitamin D3 5000IU (check levels — low in most Lyme patients)

Post-Treatment Lyme (PTLDS) Recovery and Neurological Restoration Diet

Western Integrative Medicine

  • A targeted recovery protocol for Post-Treatment Lyme Disease Syndrome — the persistent symptoms (fatigue, cognitive impairment, joint pain, mood disturbance) experienced by 10–15% of Lyme patients after completing antibiotic or herbal treatment.
  • PTLDS is characterised by HPA axis dysregulation (blunted cortisol rhythm), mitochondrial dysfunction (impaired cellular ATP production), persistent low-grade neuroinflammation (microglial activation), nervous system sensitisation, and immune system exhaustion.
  • This diet shifts focus from anti-borrelial action to neurological restoration, mitochondrial repair, HPA axis recalibration, and immune system rebuilding — while maintaining anti-inflammatory nutrition to suppress the residual neuroinflammation driving symptoms.
  • Lion's Mane NGF stimulation for cognitive recovery becomes the primary herbal intervention at this stage.

Foods:

  • Lion's Mane mushroom daily (NGF — cognitive restoration, nerve repair)
  • Wild salmon and sardines (omega-3 EPA/DHA — neuroinflammation resolution, 4–5×/week)
  • Eggs daily (choline — acetylcholine for cognitive function, B12)
  • Adaptogenic mushrooms: Reishi + Cordyceps (HPA axis, mitochondrial ATP)
  • Eleuthero and Ashwagandha teas (cortisol rhythm restoration)
  • Dark chocolate 85%+ (PEA, anandamide — mood support; flavanols — cerebrovascular flow)
  • Walnuts and avocado (DHA, B6, magnesium — brain and nerve restoration)
  • Dark leafy greens 2+ cups daily (folate, magnesium — nerve excitability normalisation)
  • Beets 3× weekly (NO — cerebrovascular and peripheral circulation support)
  • CoQ10 supplement 200–400mg daily (mitochondrial energy production — PTLDS fatigue)

Timing:

  • Morning ritual: Immune recovery juice (spinach, kale, ginger, Lion's Mane powder, eleuthero powder, lemon) + PTLDS herb tincture (Eleuthero + Astragalus + Reishi)
  • Breakfast: 3 eggs + avocado + spinach + Lion's Mane mushroom tea (NGF daily ritual) + CoQ10 supplement
  • Lunch: Salmon over large green salad with walnuts, beet, olive oil dressing + Lion's Mane capsule
  • Afternoon: Eleuthero-ginger adaptogenic tea + 1 square dark chocolate (85%) + 30g walnuts
  • Dinner: Sardines or mackerel + roasted beets + wilted kale with garlic + quinoa
  • Daily supplements for PTLDS: CoQ10 (mitochondria) 200–400mg, Lion's Mane 1.5–3g, Methylcobalamin 1000mcg, Magnesium glycinate 400mg, R-ALA 300mg (mitochondrial antioxidant), Fish oil 3g EPA+DHA, Vitamin D3 (check levels — maintain 60–80 ng/mL)
  • Sleep support critical for PTLDS: Valerian + passionflower tea before bed — non-restorative sleep perpetuates all PTLDS symptoms

16:8 Intermittent Fasting Protocol

Western Integrative Medicine

  • The most researched fasting protocol — eating within an 8-hour window and fasting for 16 hours daily.
  • During the fasting window, the body depletes glycogen and switches to fat oxidation, increasing AMPK activity, insulin sensitivity, and autophagy.
  • Benefits include reduced fasting insulin, improved metabolic flexibility, reduced inflammation markers (CRP, IL-6), and weight management.
  • The eating window is typically 10 am–6 pm or 12 pm–8 pm depending on lifestyle.

Foods:

  • Fasting window (16 hours): water only, black coffee, plain herbal tea, sparkling water
  • Breaking the fast: start with protein and fat — not carbohydrates (blunts the insulin spike after fasting)
  • Eating window (8 hours): normal anti-inflammatory whole foods
  • Avoid: fruit juice, BCAA supplements, bone broth with calories during fasting window — these partially break the fast
  • Electrolytes during fasting window: pinch of sea salt + a few drops of lemon juice if hunger is severe

Timing:

  • 12 pm (break fast): Wild salmon + 2 eggs + spinach + avocado — protein-fat first meal
  • 3 pm: Main nourishing meal — baked chicken + sweet potato + roasted vegetables
  • 6 pm (final meal): Light protein dinner — fish or chicken + non-starchy vegetables only

12 pm — Breaking the Fast

Salmon & Egg Break-Fast Plate

  1. Break your fast with protein and fat — not carbohydrates. This prevents the sharp insulin spike from carbohydrates after a 16-hour fast, maintaining the metabolic benefits.
  2. Scramble eggs slowly in butter on low heat until creamy.
  3. Sauté spinach in olive oil 1–2 minutes. Plate everything with sliced avocado.
  4. Eat slowly. After 16 hours of fasting, the digestive system needs gentle reintroduction — avoid large portions immediately.

3 pm — Main Meal

Herb-Roasted Chicken with Sweet Potato & Vegetables

  1. Preheat oven to 200°C. Toss sweet potato and vegetables with 2 tbsp olive oil, garlic, and herbs.
  2. Rub chicken with remaining olive oil and herbs. Place on tray with vegetables.
  3. Roast 22–25 minutes until chicken is cooked and vegetables have caramelised edges.
  4. Squeeze lemon over everything before serving.

6 pm — Final Meal (fasting window begins after this)

Light Fish Dinner with Green Vegetables

  1. Pan-sear fish in olive oil 3–4 minutes per side over medium heat.
  2. Steam or roast asparagus and courgette alongside. Wilt spinach in the pan.
  3. Plate and squeeze lemon over everything. Keep the meal light — you want digestion complete before sleep for better overnight autophagy.
  4. Drink herbal tea 30 minutes after. After this, fasting window begins — water, black tea, and herbal tea only until 12 pm tomorrow.

5:2 Modified Fasting Protocol

Western Integrative Medicine

  • Five days of normal eating and two non-consecutive restricted days (500 kcal for women, 600 kcal for men) per week.
  • The calorie-restricted days trigger the same metabolic benefits as full fasting — AMPK activation, reduced IGF-1, increased autophagy — but are more sustainable for most people.
  • The two fasting days should not be consecutive (e.g.
  • Monday and Thursday).
  • On fasting days, the goal is maximum nutrient density within the calorie limit.

Foods:

  • Fasting days: 500–600 total calories divided between 2 small meals
  • Fasting day proteins: eggs (70 kcal each), white fish (120 kcal per 150g), tofu (80 kcal per 100g)
  • Fasting day vegetables: unlimited non-starchy — broccoli, spinach, courgette, cucumber, celery
  • Non-fasting days: normal anti-inflammatory Mediterranean eating — no restriction
  • All days: minimum 2L water, black coffee and herbal tea allowed without breaking fast
  • Avoid: fasting on consecutive days, exercising strenuously on fasting days

Timing:

  • Fasting day breakfast (~150 kcal): 2 eggs any style (140 kcal) + unlimited herbal tea
  • Fasting day dinner (~350–450 kcal): white fish + steamed broccoli + leafy salad with lemon dressing
  • Normal day template: full Mediterranean anti-inflammatory meals without calorie restriction

Fasting Day — Breakfast (~150 kcal)

Two-Egg Fasting Breakfast

  1. Boil, poach, or scramble eggs without added oil or butter on a fasting day.
  2. Season lightly with sea salt. Drink plenty of water.
  3. Black coffee can be taken before this meal — it extends the fasting window's metabolic benefit.
  4. Total: approximately 140–150 kcal. Remaining 350–450 kcal budget is for dinner.

Fasting Day — Dinner (~400 kcal)

Fasting Day White Fish Plate

  1. Steam or bake fish in foil with lemon, herbs, and a tiny amount of olive oil. 15 minutes at 180°C.
  2. Steam broccoli and courgette 5–7 minutes until tender but not mushy.
  3. Dress salad with lemon juice only (no oil) to keep calories low.
  4. Total plate: approximately 335–370 kcal. Well within the 500 kcal fasting day budget.

Non-Fasting Day — Dinner (unrestricted)

Mediterranean Salmon with Legumes

  1. Roast vegetables with 2 tbsp olive oil at 200°C for 20 minutes.
  2. Pan-sear salmon in remaining olive oil 3–4 minutes per side.
  3. Toss chickpeas or lentils through the roasted vegetables.
  4. Plate and squeeze lemon over. Normal day — eat to comfortable fullness.

Circadian Rhythm Eating (Solar Fasting Protocol)

Ayurveda

  • Aligned with Ayurvedic principles of Agni (digestive fire) and modern circadian biology — the digestive system is strongest between 10 am and 2 pm (peak sun, peak metabolic enzyme activity) and weakest after sunset.
  • Eating after dark suppresses melatonin, increases insulin resistance by 20–30%, and disrupts circadian-regulated metabolic processes.
  • This protocol concentrates the largest meal at midday, uses a light early breakfast (or skips it), and ends all eating by 6–7 pm for a 14–16 hour overnight fast.

Foods:

  • Morning (optional, light): small amount of soaked nuts or fruit — never a heavy meal before 9 am when Agni is still awakening
  • Midday (main meal, 11 am–2 pm): largest meal of the day — all food groups, full nutrition
  • Evening (before 6 pm, very light): easily digestible — soup, cooked vegetables, small amount of protein
  • After 6–7 pm: only herbal tea, water — fasting window begins with sunset
  • Avoid: eating after 7 pm (reverses circadian metabolic benefits), heavy breakfast
  • Turmeric
  • Amla (Indian Gooseberry)
  • Licorice Root (Yashtimadhu)
  • Pippali (Long Pepper)
  • Cardamom
  • Bitter Melon

Timing:

  • Morning 8 am (optional, very light): 30g soaked almonds + 1 small banana + ginger herbal tea
  • Midday 12–1 pm (main meal): Substantial kitchari or grilled fish + rice + roasted vegetables + ghee
  • Evening before 6 pm (light): Clear vegetable soup or congee — never a heavy meal

Morning (8 am) — Optional Light Breakfast

Soaked Almond & Ginger Awakening

  1. The night before: place almonds in a bowl, cover with water, soak overnight at room temperature.
  2. In the morning: drain almonds and peel the skins off (they slide off easily after soaking — peel is astringent).
  3. Eat almonds slowly and chew thoroughly. Digestive enzyme activity is still low at 8 am.
  4. Drink ginger tea alongside — ginger gently awakens Agni without overstimulating digestion.
  5. Keep this meal very small — the purpose is to gently start digestion, not to fully feed.

Midday (12–1 pm) — Main Meal at Peak Agni

Golden Kitchari — Ayurvedic Complete Meal

  1. Rinse mung dal and rice until water runs clear.
  2. Heat ghee in a pot over medium heat. Add cumin seeds and cook 30 seconds until fragrant.
  3. Add ginger, turmeric, and coriander. Stir 30 seconds.
  4. Add dal and rice, stir to coat in ghee and spices. Pour in water or broth.
  5. Bring to a boil, reduce heat, cover and cook 25–30 minutes until dal breaks down into a thick, porridge-like consistency.
  6. Stir in cooked vegetables 5 minutes before end. Season with sea salt.
  7. Eat this as the main meal of the day, mindfully, sitting down, without screens. Agni is strongest now.

Evening (before 6 pm) — Light Closing Meal

Light Vegetable Broth Soup

  1. Simmer vegetables in broth with spices 15–20 minutes until very soft.
  2. Blend half or all for a smooth soup if desired. Stir in ghee at the end.
  3. Eat before 6 pm. This should be light and easy to digest — the digestive system is slowing down.
  4. After this meal: only herbal tea and water. The 14–16 hour overnight fast begins here.

72-Hour Autophagy Reset Fast

Western Integrative Medicine

  • An extended 72-hour fast activates deep cellular autophagy (cellular self-cleaning) — the process in which cells break down and recycle damaged organelles, misfolded proteins, and dysfunctional mitochondria.
  • The first 16–24 hours triggers glycogen depletion and ketogenesis; hours 24–72 see peak autophagy and a significant reduction in circulating IGF-1 and inflammatory cytokines.
  • After 72 hours, the immune system undergoes partial renewal (Valter Longo stem cell research).
  • This is an intensive protocol — not for weekly use.
  • Once per month or per quarter for immune reset is appropriate.

Foods:

  • During fast (72 hours): water only, electrolytes (sea salt + potassium from lemon), plain black coffee, plain herbal tea
  • No calories during the fast — bone broth, BCAA supplements, and sweetened teas partially break autophagy
  • Electrolyte maintenance: ½ tsp sea salt + squeeze of lemon in 1L water each day prevents low sodium, headache, and heart palpitation
  • Breaking the fast correctly is critical — refeeding syndrome is a risk after extended fasting. Start with bone broth, not a large meal
  • Not appropriate for: pregnant women, diabetics on insulin, anyone underweight, or anyone with a history of eating disorders

Timing:

  • Evening before Day 1 (pre-fast final meal): high-fat, high-protein — sustains energy into the fast
  • During fast (Days 1–3): water + herbal teas + black coffee + sea salt electrolyte water
  • Breaking the fast (end of Day 3): bone broth first, then 2 hours later soft scrambled eggs and avocado

Evening Before the Fast — Final Pre-Fast Meal

High-Fat, High-Protein Pre-Fast Plate

  1. This meal should be substantial but not overly large. Eat until satisfied, not stuffed.
  2. Roast salmon and vegetables at 200°C for 20 minutes with olive oil.
  3. Scramble eggs in remaining olive oil. Serve everything together.
  4. After this meal: stop eating. The fast begins now. Last coffee or herbal tea allowed until bedtime.

During the Fast (Days 1–3) — Fasting Drink Protocol

Electrolyte Fasting Water

  1. Mix electrolyte water each morning. Drink at least 2.5–3L of fluid daily during the fast.
  2. Sip throughout the day rather than drinking large volumes at once.
  3. Hunger peaks at hours 16–20 and again at hour 36 — these are temporary. After hour 48, many people experience a significant reduction in hunger.
  4. If feeling weak, dizzy, or experiencing heart palpitations: increase sea salt immediately — this is low sodium, not low blood sugar.
  5. Do not exercise intensely during hours 24–48 — light walking only. Light exercise is fine after hour 48.

Breaking the Fast (End of Hour 72) — Refeeding Protocol

Bone Broth Refeeding Sequence

  1. CRITICAL: Do not break an extended fast with a large meal. Refeeding syndrome is a medical risk with electrolyte imbalance.
  2. Start with 200ml warm bone broth. Sip slowly over 20 minutes.
  3. Wait at least 2 hours before eating anything else. Let the digestive system re-activate gently.
  4. First solid meal: 2 scrambled eggs + ¼ avocado + a little cooked spinach. Small portion.
  5. Wait 4 hours before eating a fuller meal. Eat only until moderately satisfied — do not eat a large meal to 'make up' for the fast.
  6. Day after the fast: normal eating resumes. The cells have completed their autophagy cycle.

OMAD — One Meal A Day Protocol

Western Integrative Medicine

  • The most condensed fasting protocol — all daily nutrition consumed within a single 1–2 hour eating window.
  • The 22–23 hour fasting window maximises autophagy, ketogenesis, and AMPK activation.
  • Requires careful nutritional planning to deliver complete macro and micronutrients in a single meal.
  • Best suited to people who have already adapted to 16:8 or 5:2 fasting.
  • Not recommended as a starting point — build up to it over several weeks.
  • Ideal eating window: 5–7 pm (dinner) to preserve social eating and performance throughout the day.

Foods:

  • The single meal must contain: 1.6–2g protein per kg bodyweight, 50–80g healthy fat, adequate fibre (25g minimum), all major micronutrients
  • Start with bone broth (10–15 minutes before the main meal) — re-engages digestive enzymes, provides collagen and electrolytes
  • Main protein: 250–350g salmon, chicken thighs, beef, or eggs
  • Healthy fat: 2–3 tbsp olive oil, ½ avocado, nuts/seeds
  • Complex carbohydrates (optional, especially for active people): 150–200g sweet potato, 1 cup legumes
  • Vegetables: minimum 400g — 4+ different colours
  • Finish: 20–30g dark chocolate + herbal tea

Timing:

  • Pre-meal (10–15 min before): 200ml bone broth — re-activates digestive enzymes, begins appetite signal
  • Main OMAD meal (5–7 pm): complete nutrient-dense plate — protein + fat + vegetables + optional complex carb
  • Post-meal: 20g dark chocolate + herbal tea — antioxidants + gentle digestive support

Pre-Meal (10 minutes before eating)

Digestive Activation Bone Broth

  1. Warm broth gently. Do not boil.
  2. Drink 10–15 minutes before the main OMAD meal.
  3. This re-activates the digestive enzyme cascade that has been dormant for 22+ hours, preventing the digestive distress that can come from eating a large meal after a long fast.

Main OMAD Meal (5–7 pm) — Complete Nutrition in One Plate

Complete OMAD Nourishment Plate

  1. Preheat oven to 200°C. Bake sweet potato whole 40 minutes (or use pre-cooked from the day before).
  2. Toss broccoli and capsicum with 2 tbsp olive oil, garlic, herbs. Roast 20 minutes alongside the potato.
  3. Pan-sear salmon or chicken in remaining oil, 4 minutes per side for salmon, 6 minutes for chicken. Finish chicken in oven if needed.
  4. Wilt spinach/kale in the hot pan 1 minute.
  5. Assemble the full plate: protein, roasted vegetables, leafy greens, avocado, pumpkin seeds. Squeeze lemon over everything.
  6. Eat slowly over 45–60 minutes. Chew thoroughly — digestive enzyme activity needs this time after a 22-hour fast.
  7. Serve yoghurt or kefir alongside for probiotics.

Post-Meal (30 minutes after eating)

Dark Chocolate & Chamomile Digestive Close

  1. Wait 20–30 minutes after the main meal before eating chocolate — this is a digestive rest period, not an extended eating window.
  2. Eat chocolate slowly, letting it melt.
  3. Sip chamomile tea. The eating window closes after this.
  4. The 22–23 hour fasting window now begins again.
How to Make This

Japanese Knotweed and Cat's Claw Anti-Borrelial Tea

The core anti-borrelial herbal tea — Japanese Knotweed resveratrol crosses the blood-brain barrier to address neurological Lyme and reduce the cytokine storm, while Cat's Claw POA alkaloids enhance macrophage activity and directly inhibit Borrelia. Together they provide both anti-microbial and anti-inflammatory action at every stage of Lyme disease. Best consumed warm and consistently daily.

Preparation:

  • Decoction: Simmer 1 tsp dried Japanese Knotweed root + 1 tsp cut Cat's Claw bark in 500ml water for 20 minutes.
  • Remove from heat and steep 10 more minutes.
  • Strain well.
  • Add raw honey and a squeeze of lemon.
  • The taste is earthy and slightly bitter — honey masks the bitterness.

Dosage:

  • 2 cups daily (morning and evening) — must be taken consistently for months for cumulative benefit.
  • This is a long-term maintenance tea, not a short-term remedy.

Traditional Chinese Medicine / Amazonian

Olive Leaf and Andrographis Antimicrobial Support Tea

A broad-spectrum antimicrobial tea covering Borrelia, Bartonella, and viral co-pathogens. Olive leaf oleuropein disrupts bacterial replication and is active against Epstein-Barr virus (commonly reactivated in chronic Lyme); Andrographis andrographolide provides direct anti-borrelial and anti-bartonella activity confirmed by Hopkins research. Best taken between meals.

Preparation:

  • Steep 2 tsp dried olive leaf + ½ tsp Andrographis powder in 300ml just-boiled water for 12 minutes.
  • Strain.
  • Add honey generously (Andrographis is extremely bitter).
  • Alternatively: brew olive leaf tea and take Andrographis in capsule form if the bitterness is intolerable.

Dosage:

  • 2 cups daily between meals.
  • Take Sarsaparilla endotoxin binder 30 minutes before if Herxheimer reactions are experienced.

Mediterranean / Ayurvedic

Eleuthero, Astragalus and Ginger Immune Restoration Tea

A daily adaptogenic immune-restoration tea for the recovery phase of Lyme disease — rebuilding the NK cell activity, T lymphocyte populations, and HPA axis function depleted by chronic Borrelia infection. Ginger adds anti-inflammatory activity and improves absorption of the adaptogenic compounds.

Preparation:

  • Simmer ½ tsp dried Eleuthero root + ½ tsp dried Astragalus root in 400ml water for 20 minutes.
  • Remove from heat, add 1 slice fresh ginger.
  • Steep 10 minutes.
  • Strain.
  • Add honey and lemon.

Dosage:

  • 2 cups daily — one in the morning, one at midday.
  • Do not drink in the evening (mild stimulant effect).
  • USE ONLY IN RECOVERY PHASE (after primary anti-borrelial treatment is established) — Astragalus contraindicated in active Borrelia infection.

Traditional Chinese Medicine / Russian Folk Medicine

Cistus

Cistus incanus

Traditionally used in Mediterranean for immune support, skin health, inflammation.

Preparation:

  • Infusion: Steep 1–2 tsp of dried Cistus in freshly boiled water for 5–10 minutes, covered.
  • Strain and drink.

Dosage:

  • 1–3 cups daily

⚠️ Not Medical Advice: This information is for educational purposes only. Always consult a qualified healthcare provider before using herbal remedies.

Avoid if:

  • Pregnancy & breastfeeding — insufficient safety data; consult your doctor
  • Children under 12 — therapeutic dosage not established
  • Autoimmune conditions (lupus, MS, RA) — may overstimulate immune response

Mediterranean

Full profile
How to Make This

Buhner Core Lyme Tincture (Cat's Claw, Japanese Knotweed, Andrographis)

The three-herb foundation of Stephen Buhner's extensively documented herbal Lyme protocol — the most widely used and clinically observed herbal approach to Lyme disease globally. Cat's Claw provides POA alkaloid immune activation and direct Borrelia activity; Japanese Knotweed resveratrol crosses the blood-brain barrier to address neurological Lyme and suppress the cytokine storm; Andrographis andrographolide provides direct anti-borrelial and anti-co-infection activity confirmed by Johns Hopkins persister cell research. Together they address Borrelia simultaneously at the immune, inflammatory, and direct antimicrobial levels.

⚠️ St. John's Wort is NOT in this formula — drug interactions from the core three-herb Buhner combination are minimal. Andrographis: not in pregnancy. Cat's Claw: not with immunosuppressants. All three: Herxheimer reactions possible when beginning. Store in a cool dark place.

Western Herbal Medicine / Integrative

Biofilm and Persister Cell Disruptor Tincture (Oregano, Cryptolepis, Artemisinin)

A targeted tincture combination for the most treatment-resistant aspects of Lyme disease — biofilm-embedded colonies and non-replicating persister cells. Oregano oil carvacrol disrupts persister cell membranes through a metabolism-independent mechanism; Cryptolepis alkaloids (cryptolepine) demonstrated superiority to doxycycline against stationary-phase Borrelia in the Johns Hopkins study; Artemisinin generates ROS that kill both persister Borrelia and intraerythrocytic Babesia. This combination specifically targets the forms of Borrelia and its co-pathogens that are not eliminated by standard antibiotic therapy.

⚠️ Artemisinin: not in pregnancy, cycle use. Oregano oil: GI irritation — use enteric-coated capsule form for the oregano component if significant GI discomfort occurs. Cryptolepis: not in pregnancy, monitor blood glucose. Herxheimer reactions likely on beginning — reduce dose or delay each herb separately to identify and manage.

Integrative Medicine / African Traditional / TCM

PTLDS Recovery and Immune Restoration Tincture (Eleuthero, Astragalus, Reishi)

An adaptogenic immune restoration tincture specifically formulated for Post-Treatment Lyme Disease Syndrome — the phase after antibiotic or anti-borrelial herbal therapy where the goal shifts from killing Borrelia to restoring the immune system, HPA axis, and mitochondrial function depleted by chronic infection. Eleuthero restores normal cortisol rhythm and NK cell activity; Astragalus rebuilds depleted T lymphocyte populations and extends immune cell lifespan through telomerase activation; Reishi mushroom (Ganoderma lucidum) beta-glucans modulate the chronic immune dysregulation and neuroinflammation of PTLDS while supporting adrenal recovery. NOTE: Astragalus is used here in the RECOVERY phase — it is contraindicated during active Borrelia infection as it may drive the organism deeper into tissue.

⚠️ Astragalus contraindicated in active Borrelia infection — use ONLY in the recovery phase after primary anti-borrelial treatment. Eleuthero: not with digoxin. Not in pregnancy. Reishi: not with anticoagulants. Mild stimulant effect — avoid in evening.

Traditional Chinese Medicine / Russian Folk Medicine

Cistus

Cistus incanus

Traditionally used in Mediterranean for immune support, skin health, inflammation.

Preparation:

  • Fill a jar with dried Cistus and cover with 40–60% alcohol.
  • Seal and steep for 4–6 weeks, shaking daily.
  • Strain and store in a dark dropper bottle.

Dosage:

  • 20–40 drops in water, 2–3× daily

⚠️ Not Medical Advice: This information is for educational purposes only. Always consult a qualified healthcare provider before using herbal remedies.

Avoid if:

  • Pregnancy & breastfeeding — insufficient safety data; consult your doctor
  • Children under 12 — therapeutic dosage not established
  • Autoimmune conditions (lupus, MS, RA) — may overstimulate immune response

Mediterranean

How to Make This

Anti-Borrelial Green Detox Juice

A daily detoxification and anti-inflammatory juice supporting the liver's processing of Borrelia die-off toxins during active Lyme treatment, while providing anti-inflammatory compounds that reduce the cytokine-driven Herxheimer reaction. Ginger and turmeric provide anti-borrelial and anti-inflammatory compounds; lemon stimulates bile flow for endotoxin elimination; celery provides phthalides that reduce systemic inflammation; beet provides liver-protective betaine and nitrates.

Preparation:

  • Juice: 1 medium beet + 2 stalks celery + 1 inch fresh ginger + 1 inch fresh turmeric + 1 lemon (peeled) + 1 cup spinach + 1 apple.
  • Stir in a drop of oregano oil diluted in 1 tsp olive oil after juicing if tolerated.
  • Drink immediately on an empty stomach.

Dosage:

  • 200–250ml daily on an empty stomach, throughout active Lyme treatment.
  • Take Sarsaparilla root tincture 30 minutes before juice if experiencing Herxheimer reactions.

Western Herbal / Mediterranean

Immune Restoration and PTLDS Recovery Juice

A nutrient-dense recovery juice for Post-Treatment Lyme Disease Syndrome — providing antioxidants to address the mitochondrial oxidative stress causing PTLDS fatigue, B vitamins for neurological recovery, magnesium for the hyperexcitable nervous system, and adaptogenic mushroom powder for immune system rebuilding.

Preparation:

  • Juice: 2 cups spinach + 1 cup kale + 1 inch ginger + ½ cucumber + 1 lemon + 1 green apple.
  • After juicing, blend or stir in: 1 tsp Lion's Mane dual-extract powder + 1 tsp spirulina + 1 tsp eleuthero powder.
  • Drink within 10 minutes.

Dosage:

  • 250ml daily on an empty stomach in the morning.
  • The Lion's Mane and Eleuthero are essential components — include them even if the full juice is not prepared (can be added to water).
  • Use daily throughout treatment and for 6–12 months post-treatment.

Traditional Chinese Medicine / Western Integrative

How to Make This

Frankincense & Rose Hip Regenerating Serum

A luxurious regenerating serum drawing on ancient Persian healing wisdom, combining frankincense resin's boswellic acids with rose hip's trans-retinoic acid to reduce inflammation, promote cellular renewal, and improve skin tone.

How to make:

  1. Combine rose hip and jojoba oils in a small dark glass bottle.
  2. Add vitamin E oil and swirl to mix.
  3. Add all essential oils.
  4. Cap tightly and shake well.
  5. Allow to rest for 24 hours before first use.

Apply: Apply 3–4 drops to clean, slightly damp skin. Press gently into skin using fingertips — do not drag. Allow to absorb for 2 minutes before applying moisturiser. — Morning and/or evening

Persian Medicine

  • Lymphatic drainage massage: gentle manual technique targeting neck, armpit, and groin lymph nodes to support immune clearance and detoxification — 20–30 min session, 2–3x/week or monthly with a trained therapist
  • Acupuncture: TCM needle therapy at condition-specific meridian points to restore Qi flow and reduce systemic inflammation — 6–12 weekly sessions recommended initially
  • Sauna therapy: infrared sauna at 50–60°C for 20–30 min, 3–4x/week — promotes detoxification through sweat, reduces inflammatory markers, and supports immune function
  • Cold plunge / contrast hydrotherapy: 30–60 seconds cold shower or cold plunge after sauna — activates the vagus nerve, reduces inflammation, and boosts circulation
  • Yoga: 30–45 min daily practice of poses suited to your condition — combines breathwork, stretching, and mindfulness to regulate the nervous system and reduce stress hormones
  • Meditation: 20 min daily — body scan, breath awareness, or loving-kindness practice to lower cortisol and support the mind-body healing response
  • Breathwork: diaphragmatic breathing or pranayama (e.g. alternate nostril, 4-7-8) for 10–15 min daily — regulates the autonomic nervous system and reduces systemic inflammation
  • Grounding / earthing: 20–30 min of barefoot contact with grass, soil, or sand daily — shown to reduce cortisol, normalise circadian rhythm, and lower inflammatory markers
  • Forest bathing (Shinrin-yoku): 60–90 min slow, mindful walk in a forested or green environment weekly — clinically shown to reduce stress hormones and blood pressure
  • Sleep hygiene: maintain a consistent sleep/wake time, keep bedroom dark and cool (18–20°C), avoid screens 1 hour before bed — 7–9 hours of quality sleep is foundational to all healing
  • Morning sunlight: 10–20 min of direct sunlight exposure before 10am daily — anchors circadian rhythm, boosts vitamin D synthesis, and regulates serotonin
  • Journaling: 10–15 min daily reflective writing — symptom tracking, emotional processing, and gratitude practice to reduce psychological stress load

Mediterranean

Ancient Greek, Roman, and Arab traditions blended into a culinary and medicinal heritage still widely practiced today.

Mediterranean addresses lyme disease support using traditional herbs, dietary adjustments, and lifestyle practices specific to its healing philosophy.

When to see a doctor

Consult a healthcare provider if your symptoms are severe, persistent, or worsening, or before starting any herbal protocol.

Sunaras provides holistic health education. Always work with a qualified healthcare practitioner.

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